Purinergic modulation of human corpus cavernosum relaxation
نویسندگان
چکیده
منابع مشابه
Experimental model of human corpus cavernosum smooth muscle relaxation.
PURPOSE To describe a technique for en bloc harvesting of the corpus cavernosum, cavernous artery and urethra from transplant organ donors and contraction-relaxation experiments with corpus cavernosum smooth muscle. MATERIALS AND METHODS The corpus cavernosum was dissected to the point of attachment with the crus penis. A 3 cm segment (corpus cavernosum and urethra) was isolated and placed in...
متن کاملExperimental study of verapamil on the relaxation of isolated human corpus cavernosum tissues.
AIM To evaluate the relaxant effect of verapamil on human corpus cavernosum in vitro and to assess the drug's potential as a treatment for erectile dysfunction (ED). METHODS Preparations of the human corpus cavernosum were obtained from recently deceased young men who had had normal erectile function. The isometric tension and detailed curves were recorded when contractions induced by 10 micr...
متن کاملHydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation.
Hydrogen sulfide (H(2)S) is synthesized by 2 enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). L-Cysteine (L-Cys) acts as a natural substrate for the synthesis of H(2)S. Human penile tissue possesses both CBS and CSE, and tissue homogenates efficiently convert L-Cys to H(2)S. CBS and CSE are localized in the muscular trabeculae and the smooth-muscle component of th...
متن کاملA functional study of purinergic signalling in the normal and pathological rabbit corpus cavernosum.
OBJECTIVE To examine rabbit cavernosal smooth muscle (CSM) relaxation to ATP, ADP and UTP in normal rabbits and in models of conditions that predispose to erectile dysfunction (ED), diabetes mellitus (DM; induced for 6 months) and bladder outlet obstruction (BOO, 6 weeks after surgery). MATERIALS AND METHODS Concentration-response curves (CRCs) were constructed to ATP, ADP and UTP on CSM from...
متن کاملTraumatic rupture of corpus cavernosum.
Traumatic rupture of corpora cavernosa is an uncommon injury. We report a case of fractured penis in a 60 year old which was managed by immediate exploration and operative repair. Post operative recovery was uneventful with full return of erectile function.
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 2009
ISSN: 0105-6263,1365-2605
DOI: 10.1111/j.1365-2605.2007.00828.x